Objective: Various personality traits have longitudinal relations with body mass index (BMI), a measure of body weight and a risk factor for numerous health concerns. We tested these associations' compatibility with causality in either direction. Method: Using three waves of the Wisconsin Longitudinal Study (N = 12,235, Mage = 53.33 at baseline), we tested how accurately the Five‐Factor Model personality domains and their items could collectively predict BMI and change in it with elastic net models. With multilevel models, we tested (a) bidirectional and (b) within‐person associations between BMI and personality traits. Results: The five domains were able to predict concurrent (r = 0.08), but not future BMI. Twenty‐nine personality items predicted concurrent and future BMI at r = 0.21 and r = 0.16 to 0.25, respectively. Neither the domains nor items could collectively predict change in BMI. Similarly, no individual trait predicted change in BMI, but BMI predicted changes in Conscientiousness, Agreeableness, and several items (|b*| = 0.03 to 0.08). BMI had within‐person correlations with these same traits; time‐invariant third factors like genetics or childhood environments therefore could not (fully) account for their relations. Conclusions: Body weight may contribute to adults' personality development, but the reverse appears less likely. [ABSTRACT FROM AUTHOR]