Tooth is a vital organ in the oral cavity that has functions for chewing, talking, swallowing, and giving facial aesthetics. Tooth decay or loss can reduce the quality of life (QOL). Nowadays, tooth decay treatment is restored through a conservative approach, which uses dental inorganic materials and their supporting tools. Besides, the loss of a tooth can be replaced by a dental prosthetic or artificial tooth. The advanced and greatly promising technology in the future is to apply the concept of regenerative dentistry as a biological repair of lost and damaged tissue using stem cells. Regenerative medicine using stem cells is promising therapeutic tool in the future to restore or replace the damage tissue into normal function by utilized their potency to differentiate into specialized cells type. This review aims to report the potential of stem cells for tooth regeneration and tissue repair in dental field. [ABSTRACT FROM AUTHOR]