Lack of asparagine depletion in the cerebrospinal fluid after one intravenous dose of PEG-asparaginase: a window study at initial diagnosis of childhood ALL.
- Resource Type
- letter
- Authors
- Appel, I. M.; Pinheiro, J. P. V.; den Boer, M. L.; Lanvers, C.; Reniers, N. C. M.; Boos, J.; Pieters, R.
- Source
- Leukemia (08876924). Nov2003, Vol. 17 Issue 11, p2254-2256. 3p.
- Subject
- *LYMPHOBLASTIC leukemia in children
*ASPARAGINASE
*POLYETHYLENE glycol
*CEREBROSPINAL fluid
*RESEARCH
*LEUKEMIA treatment
*THERAPEUTICS
- Language
- ISSN
- 0887-6924
Discusses the role of asparaginase (ASP) in treatment of children with acute lymphoblastic leukemia. Revelation that different preparations and ways of administration of ASP results in different plasma activities; Description of functioning of ASP; Information that pharmacokinetics and pharmacodynamics of polyethylene glycol-ASP are not well characterized in the cerebrospinal fluid (CSF); Explanation for the lack of depletion of asparagine depletion in CSF.