Bar = 60 µm for a, b; 30 µm for c, d; 10 µm for e-i, l; 15 µm for j, m; 6 µm for k The neuropathologic features of this patient were indistinguishable from those of ALS without known mutations, except for the presence of annexin A11-ir NCIs, being similar to the previously reported patient with I ANXA11 i mutation (Table 2) [[6]]. Morphologically, the annexin A11-ir NCIs in this patient differed slightly from those in the previous patients with N-terminal I ANXA11 i mutation [[6]]. To the editor Mutations in the annexin A11 gene ( I ANXA11) i have been shown to cause amyotrophic lateral sclerosis (ALS) [[6]]. 2 Position of the identified ANXA11 mutation and biological characteristics of the mutant annexin A11. a Annexin A11 protein domains and the position of mutations identified in patients with amyotrophic lateral sclerosis (ALS). [Extracted from the article]