An abnormal phenotype of lung Vγ9Vδ2 T cells impairs their responsiveness in tuberculosis patients.
- Resource Type
- Article
- Authors
- El Daker, Sary; Sacchi, Alessandra; Montesano, Carla; Altieri, Alfonso Maria; Galluccio, Giovanni; Colizzi, Vittorio; Martini, Federico; Martino, Angelo
- Source
- Cellular Immunology. Apr2013, Vol. 282 Issue 2, p106-112. 7p.
- Subject
- *TUBERCULOSIS patients
*PHENOTYPES
*MYCOBACTERIUM tuberculosis
*T cells
*CELLULAR immunity
*PERIPHERAL nervous system
*PHYSIOLOGY
- Language
- ISSN
- 0008-8749
Highlights: [•] γδ T cells play an important role during early phases of MTB infection. [•] BAC Vγ9Vδ2 T cells present a strong down modulation of CD3 expression compared with their counterpart in peripheral blood. [•] BAC Vγ9Vδ2 T cells express different phenotype compared to circulating Vγ9Vδ2 T cells. [•] Vγ9Vδ2 T cell functions are specifically impaired in situ by active TB. [ABSTRACT FROM AUTHOR]