The Role of Focal Adhesion Kinase-Phosphatidylinositol 3-Kinase-Akt Signaling in Hepatic Stellate Cell Proliferation and Type I Collagen Expression.
- Resource Type
- Article
- Authors
- Reif, Shimon; Alon Lang; Lindquist, Jeffery N.; Yata, Yutaka; Gäbele, Erwin; Scanga, Andrew; Brenner, David A.; Rippe, Richard A.
- Source
- Journal of Biological Chemistry. 3/7/2003, Vol. 278 Issue 10, p8083. 8p. 1 Diagram, 11 Graphs.
- Subject
- *FOCAL adhesion kinase
*COLLAGEN
*PLATELET-derived growth factor
- Language
- ISSN
- 0021-9258
Studies the role of focal adhesion kinase-phosphatidylinositol 3-kinase(PI3K)-akt signaling in hepatic stellate cell (HSC) proliferation and type I collagen expression. Activation of the focal adhesion kinase (FAK)-PI3K-Akt signaling pathway by platelet-derived growth factor; Stimulation of HSC proliferation in serum-starved HSC; Regulation of type I collagen by the PI3K-Akt signaling pathway.