Ruthenium(II)‐Catalyzed Double Annulation of Quinones: Step‐Economical Access to Valuable Bioactive Compounds.
- Resource Type
- Article
- Authors
- Silva Júnior, Eufrânio N.; Carvalho, Renato L.; Almeida, Renata G.; Rosa, Luisa G.; Fantuzzi, Felipe; Rogge, Torben; Costa, Pedro M. S.; Pessoa, Claudia; Jacob, Claus; Ackermann, Lutz
- Source
- Chemistry - A European Journal. 8/26/2020, Vol. 26 Issue 48, p10981-10986. 6p.
- Subject
- *RUTHENIUM
*ANNULATION
*BIOACTIVE compounds
*RUTHENIUM catalysts
*POLYCYCLIC compounds
*QUINONE
- Language
- ISSN
- 0947-6539
Double ruthenium(II)‐catalyzed alkyne annulations of quinones were accomplished. Thus, a strategy is reported that provides step‐economical access to valuable quinones with a wide range of applications. C−H/N−H activations for alkyne annulations of naphthoquinones provided challenging polycyclic quinoidal compounds by forming four new bonds in one step. The singular power of the thus‐obtained compounds was reflected by their antileukemic activity. [ABSTRACT FROM AUTHOR]