ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer
- Resource Type
- Article
- Authors
- Kalyuga, Maria; Gallego-Ortega, David; Lee, Heather J.; Roden, Daniel L.; Cowley, Mark J.; Caldon, C. Elizabeth; Stone, Andrew; Allerdice, Stephanie L.; Valdes-Mora, Fatima; Launchbury, Rosalind; Statham, Aaron L.; Armstrong, Nicola; Alles, M. Chehani; Young, Adelaide; Egger, Andrea; Au, Wendy; Piggin, Catherine L.; Evans, Cara J.; Ledger, Anita; Brummer, Tilman
- Source
- PLoS Biology. Dec2012, Vol. 10 Issue 12, p1-17. 17p. 6 Diagrams, 2 Graphs.
- Subject
- *ESTROGEN
*ESTROGEN antagonists
*BREAST cancer
*IMMUNOPRECIPITATION
*GENE expression
*CANCER prognosis
- Language
- ISSN
- 1544-9173
The transcription factor ELF5 is responsible for gene expression patterning underlying molecular subtypes of breast cancer and may mediate acquired resistance to anti-estrogen therapy. [ABSTRACT FROM AUTHOR]