Deep fluid circulation likely triggered the large extensional events of the 2016–2017 Central Italy seismic sequence. Nevertheless, the connection between fault mechanisms, main crustal‐scale thrusts, and the circulation and interaction of fluids with tectonic structures controlling the sequence is still debated. Here, we show that the 3D temporal and spatial mapping of peak delays, proxy of scattering attenuation, detects thrusts and sedimentary structures and their control on fluid overpressure and release. After the mainshocks, scattering attenuation drastically increases across the hanging wall of the Monti Sibillini and Acquasanta thrusts, revealing fracturing and fluid migration. Before the sequence, low‐scattering volumes within Triassic formations highlight regions of fluid overpressure, which enhances rock compaction. Our results highlight the control of thrusts and paleogeography on the sequence and hint at the monitoring potential of the technique for the seismic hazard assessment of the Central Apennines and other tectonic regions. Plain Language Summary: There is widespread evidence that the Amatrice‐Visso‐Norcia seismic sequence (2016–2017, Central Italy) was triggered by fluid circulation across the Apennine Chain. However, how, and why fluids migrated across the fault network is still under debate. Seismic attenuation describes how seismic waves lose energy during their propagation. When used as an imaging attribute, it has demonstrated the potential to recover the spatial extension and mechanisms of fracturing and fluid movement across volcanoes and faults. Here, we map scattering attenuation through the peak delay measurements in 3D before (2013–2016) and during the 2016–2017 sequence. Scattering attenuation separated fractured zones from regions of compaction, controlled, before and during the sequence by thrusts and lithological differences. High scattering (strong fracturing) increases through time due to intense fracturing, while low scattering (higher compaction of the rocks) marks areas where earthquakes will occur. Our results highlight the importance of the main thrusts, as they separate compartments of the shallow crust characterized by different scattering attenuation anomalies, the Triassic deposits in fluid accumulation, and subsequent triggering of normal faults. Key Points: Scattering attenuation detects the control of thrusts and lithology on post‐seismic fracturing and fluid migration during the AVN sequenceOverpressurized fluids compact low‐scattering rocks at thrusts' roots before earthquakesDetecting fluid overpressure and fracturing suggests an unexploited monitoring potential of scattering attenuation [ABSTRACT FROM AUTHOR]