Mango is the tropical and subtropical tree fruit and known as the king of all fruits. Its production is continuously declining due to diseases incidence and insect pest attacks. Mango sudden death syndrome is the deadly disease of mango trees in many countries around the world. The objective of the current study was to study the effect of sudden decline on the transport of macronutrients (P, K, Ca, Mg), micronutrients (Fe, B, Mn, Cr, Zn, Cu, Mo, Ni), beneficial nutrients (Al, Co, Na, Si), toxic elements (Ba, Pb, Sr, Cd), water and ash contents in healthy and infected tissues of stem bark and aerial parts of mango tree. Sudden death disease significantly (p<0.05) decreased water contents in infected tissues as compared to healthy tissues which were taken as control. The quantitative mineral analysis was carried out by inductively coupled plasma-optical emission spectrometry (ICP-OES). The levels of Ba, Mn, K, B, Al, Fe, Mg, Na, Ca, Sr, Cd, Ni, Cr, Pb, Mo significantly reduced by 11.53, 12.16, 12.18, 17.40, 23.33, 26.04, 31.27, 31.46, 35.89, 39.47, 40, 40.28, 51.15, 60.00 and 71.42%, respectively, in infected stem bark as compared to healthy control. Similarly, the levels of Ni, Zn, Si, Co, Sr decreased in infected aerial parts by 10.22, 27.22, 32.07, 39.47 and 80%, respectively, as compared to healthy control. It was revealed that sudden death disease causes significant nutritional imbalance in stem bark and aerial parts of the mango plant. The present study indicated the decreased level of essential nutrients as one of the predisposing factors causing sudden death of mango trees. The findings of this study provided valuable information to manage the nutritional status of diseased mango plants in future and for the development of mango varieties resistant to changes in mineral nutrients under exposure to sudden death disease. [ABSTRACT FROM AUTHOR]