Combination of vinorelbine plus gemcitabine in previously treated patients with small cell lung cancer: A multicentre phase II study
- Resource Type
- Article
- Authors
- Rapti, Ageliki; Agelidou, Athina; Stergiou, Ioannis; Agelidou, Maria; Nikolakopoulos, Ioannis; Varthalitis, John; Kalykaki, Antonia; Chainis, Kyriakos; Tzanakis, Nikolaos; Georgoulias, Vassilis
- Source
- Lung Cancer (01695002). Aug2005, Vol. 49 Issue 2, p241-244. 4p.
- Subject
- *LUNG cancer
*CANCER patients
*VINORELBINE
*ANTINEOPLASTIC agents
- Language
- ISSN
- 0169-5002
Summary: Purpose:: To evaluate the efficacy and toxicity of the gemcitabine plus vinorelbine combination in pretreated patients with small cell lung cancer (SCLC). Patients and methods:: Thirty-five pretreated patients (median age 59 years, PS: 0–1 in 97% and 2 in 3%) were treated with gemcitabine (1100mg/m2) and vinorelbine (25mg/m2) on d1 and d8 every 3 weeks. Seven (20%) patients were treated with two prior regimens and 20 (57%) were refractory to front-line chemotherapy. Results:: In an intention-to-treat analysis two (6%) partial responses (PR) were observed with a duration of 5.6 and 11.1 months. Stable disease (SD) was documented in 8 (23%) patients and progressive disease (PD) in 25 (71%). The overall median survival was 4.5 and the 6 months survival rate was 42.6%. Grades 3–4 neutropenia and thrombocytopenia were observed in 25 and 14% of the patients, respectively. Non-hematological toxicity consisted of grade 2 neurotoxicity occurring in 14% of the patients and grades 2–3 fatigue in 17%. Febrile neutropenia was observed in three (8.6%) patients and one of them died from sepsis. Conclusion:: The combination of gemcitabine plus vinorelbine cannot be considered as an effective salvage treatment in pretreated patients with SCLC. [Copyright &y& Elsevier]