Novel chiral ionic liquid (CIL) assisted selectivity enhancement to (L)-proline catalyzed asymmetric aldol reactions
- Resource Type
- article
- Authors
- Zhang, Long; Zhang, Haibo; Luo, Huadong; Zhou, Xiaohai; Cheng, Gongzhen
- Source
- Journal of the Brazilian Chemical Society. September 2011 22(9)
- Subject
- aldol reaction
asymmetric synthesis
chiral ionic liquids
chiral additive
- Language
- English
- ISSN
- 0103-5053
A significant improvement of the chemical yields (up to 88%), stereoselectivity (> 99:1) and enantiomeric excesses (up to 98%) of (L)-proline catalyzed direct asymmetric aldol reaction was found when proline based chiral ionic liquids (CILs) were added as additives. Different ratios of DMSO/H2O as solvent and chiral ionic liquids (CILs) with chiral cations of different chain length were investigated