Microwave assisted synthesis of 6-Substituted aminopurine analogs in water
- Resource Type
- article
- Authors
- Qu, Guirong; Han, Suhui; Zhang, Zhiguang; Geng, Mingwei; Xue, Feng
- Source
- Journal of the Brazilian Chemical Society. October 2006 17(5)
- Subject
- amination
6-substituted aminopurine analogs
nucleophilic substitution
microwave irradiation
amines
- Language
- English
- ISSN
- 0103-5053
Microwave assisted amination of 6-chloropurine derivatives with various amines in water resulted in a "green chemistry" protocol for the preparation of 6-substituted aminopurine analogs in very good yields. Using a simply modified microwave oven with the refluxing apparatus, the amination of the 6-chloro in the purine structure occurred smoothly. 19 known and 16 unknown 6-substituted aminopurine analogs were prepared through nucleophilic aromatic substitution with simple filtration or column chromatography.