Emergence of GM(genetically-modification)technology is a leap in biotechnology. GM technology in food production marks the establishment of GM food industry. Along with the popularization of GM technology and product, till 2014, there have been 28 countries allowing the cultivation of GM crops planting with area up to 181.5 million hectares. GM crops has become one of the fastest growing bio-technologies. However, GM food popularization and development of the industry has been plagued by public controversy. While there is more emphasis on GM technology research and development in many countries and regions, the argument concerning the safety of GM foods has been constant. Due to the difference of culture, technology, economic background, the legal framework and regulation for GM food varies. EU has the most stringent regulation on GM food safety, while the regulation in the United States is very accommodating. Japan, South Korea, and some other countries have been looking for a balance between EU and the United States, allowing the circulation with simultaneous supervision regulation. At present, China has GM food both in planting and in circulation. However, the development of GM food safety legislation and supervision in China is relatively slow. Due to lack of regulation, the problem of unapproved GM food entering the market and other issues have been gradually exposed to the public. Therefore, it is nowhere near enough to establish and improve the safety of GM food regulatory system in China. Taking three advanced economies like the United States, European Union, and South Korea as a reference, this paper has proposed the improvement advice to the GM food safety management in China. The first chapter of this paper introduces the research background, significance and the outcomes of preliminary research. The second chapter elaborates the safety evaluation of GM food. The third chapter introduces the safety management system of GM food in the United States, EU, and South Korea, including regulatory institute, legislative principles, safety evaluation system, commercial censorship, identification systems, etc. then compares the three management systems, and explains the reason of the difference. Chapter IV describes the existing Chinese GM safety management system and the emergence of related social issues. By deriving the problem of China in GM food safety management system, it proposes the improvement plan with reference to the best practice from the US, Europe, and Korea. The fifth chapter is the conclusion of the whole thesis. This paper thoroughly analyzed the GM food safety management system in China, pointed out the existing problems, such as lack of legislation, unreasonable safety standards, inadequacy in safety evaluation and commercialization approval, imperfect labeling system and lack of supervision, etc. The improvement plan is proposed based on the safety management scheme in Korea, with reference to the system of EU and the US. For improving the management system, it suggests to clarify a legislative principle, introduce high-level legal act, harmonize safety standards; for improving safety evaluation system, it suggests to distinguish between humans and the environment as two separated aspects; For commercialization approval system, it suggests to conduct the approval according to usage type and establish the public participation and approval system, then setup the real-time monitoring system to ensure timely response to emergencies; labeling system should be established in order to identify the minimum content; finally, to establish the public monitoring system, so as to enable the public opinion supervision on GM food safety management.