트리뷰티린 에멀젼을 이용한 파클리탁셀 가용화 및 항암활성에 관한 연구 / A Study On Solubilization And Anticancer Activity Of Paclitaxel Using Tributyrin Emulsion
- Resource Type
- Dissertation/ Thesis
- Authors
- 비상 / Fei, Xiang
- Source
- Subject
- Emulsion
Paclitaxel
Drug delivery
Tributyrin
- Language
- English
1.1. ABSTRACTA Study On Solubilization And Anticancer Activity Of Paclitaxel Using Tributyrin EmulsionFei, XiangDepartment of Pharmaceutical EngineeringGraduate School of Woosuk University(Directed by Professor Kim Jonghwa)A thesis presented on the study of drug delivery system using Tributyrin emulsion with the purpose of improving the solubility and the anticancer activity of paclitaxel. The use of short chain fatty acid Tributyrin emulsion was able to increase the solubility and anticancer activity of drug in comparison to the medium-chaintriglycerides Labrafac?? formulation. After High-pressure homogenizer process particle size of emulsion significant decreased and showed narrow particle size distribution. Cytotoxicity in human breast cancer cell lines MCF-7 of our paclitaxel formulation was more potent compared to paclitaxel in DMSO. In conclusion, the Tributyrin emulsion might be a promising carrier for paclitaxel and other poorly soluble drugs.Keywords: Emulsion; Paclitaxel; Tributyrin; Drug delivery