With the development of the knowledge and economy, the relationship between regional economic development and local universities has become closer. They are both interdependent and inter growth. With the regional economy development and the formation of its own economic characteristics, there is an urgent need for cooperation with higher education. However, there are some problems in the development positioning of some local universities, such as blind development goals, lack of school-running characteristics, profit-seeking of education function and confused service-oriented. Therefore, the author would study form the problems, take Yanbian University as an example, and put forward the reasonable development mechanism research on the basis of the analysis of the localization of him local universities. To set development goals that are in line with reality and within the limits of our capabilities, school-running characteristics of inheriting culture and innovative development, educational function of all-round development, make local universities clarify their service targets and serve the local economy better. Establishes service-oriented industry-university-research cooperation mechanism and a teacher evaluation mechanism of emphasizing difference and seeking development. So as to achieve the goal of local economic development and local universities joint promotion and mutual development. As a local universities, Yanbian university can build a highland for training talents in the Tumen River region and a base for talent and technology export at all levels, and Developmentally achieve the overall sharing of educational resources. Promote the development of the local economy to the greatest extent, so as to achieve the goal of mutual promotion and development between the local economy and local universities.