In the face of the development environment of digital technology at home and abroad, this paper firstly expounded the definition, characteristics and the scope of digital publishing & big data, combined with the characteristics of big data era, analyzed the latest development of digital publishing industry practice, such as Big data driven digital products the integration of production,Big data driven digital products personalized customization, Big data driven digital publishing precision marketing, Big data driven crossover combination of digital content, Big data driven digital content Readers customization, Big data driven digital content to optimize the user's reading experience. Secondly, this paper combed the connotation of digital publishing talent work and analyzed digital publishing talent training status quo and existing problems, such as the curriculum needs further systematic, professional and technical research and teachers need to be further improved, the experimental course setting time is short, etc. Finally, in this paper trying to build multi-level talent cultivation system based on the talent training knowledge system,talent training ability system and talent training model system.