This paper empirically analyzes the impact of Northeast China's trade with Russia of the impact on regional economic growth in Northeast China. Since China and Russia geographically have closed, so not only from the economic viewpoint of the regional economic growth, but also from the regional cooperation viewpoint with neighboring countries has the important significance. This paper is based on the existing research, and different from the another research, tried to improve the research methods, and attempt to merge the effect of the trade, establish a panel regression models. The regression model is based on the regional economic growth model, and includes labor and capital , and includes the export and import. According to the results, Northeast China and Russia's exports, and import have a positive impact on the regional economic growth in Northeast China, and has a statistically significant. As can be seen in Northeast China's trade with Russia on regional economic growth is important, from a regional perspective, Heilongjiang province is relatively more obvious regional economic growth.