Based on the finite element models of three different span bridges established by using the parameters of medium and small-span continuous girder bridges with plate rubber bearings on a highway in Yunnan, this paper mainly discusses the influence degree and law of pier height, site type, fault distance, and velocity pulse on the seismic response, and the influence of span and PGA on seismic response is also reflected. Finally, the seismic performance of bridges under different earthquake cases is evaluated.