The prognostic miR-532-5p-correlated ceRNA-mediated lipid droplet accumulation drives nodal metastasis of cervical cancer
- Resource Type
- article
- Authors
- Chunliang Shang; Yuan Li; Tianhui He; Yuandong Liao; Qiqiao Du; Pan Wang; Jie Qiao; Hongyan Guo
- Source
- Journal of Advanced Research, Vol 37, Iss , Pp 169-184 (2022)
- Subject
- miRNA prognostic model
Lipid droplet
FASN
Lymph node metastasis
Cervical cancer
Medicine (General)
R5-920
Science (General)
Q1-390
- Language
- English
- ISSN
- 2090-1232
Introduction: The prognosis for cervical cancer (CC) patients with lymph node metastasis (LNM) is extremely poor. Lipid droplets (LDs) have a pivotal role in promoting tumor metastasis. The crosstalk mechanism between LDs and LNM modulated in CC remains largely unknown. Objectives: This study aimed to construct a miRNA-dependent progonostic model for CC patients and investigate whether miR-532-5p has a biological impact on LNM by regualting LDs accumulation. Methods: LASSO-Cox regression was applied to establish a prognostic prediction model. miR-532-5p had the lowest P-value in RNA expression (P