Competing Interests: Conflicts of interest Fabio Turco and Matthew Smith have nothing to disclose. Aurelius Omlin has received institutioanl advisory fees from AstraZeneca, Astellas, Bayer, Janssen, Molecular Partners, MSD, Pfizer, Roche, and Sanofi Aventis; institutional research support from TEVA and Janssen; travel support from Astellas, Bayer, Janssen, and Sanofi Aventis; and institutional speaker bureau fees from Bayer, Astellas, and Janssen. Silke Gillessen has received personal honoraria for participation in advisory boards from Sanofi, Orion, Roche, Amgen, and MSD, and other honoraria from Televisione Svizzera Italiana; has been an invited speaker for ESMO, the Swiss Group for Clinical Cancer Research (SAKK), the Swiss Academy of Multidisciplinary Oncology (SAMO), the Orikata Academy Research Group, and the China Anti-Cancer Association Genitourinary Oncology Committee (CACA-GU); participates in a speaker bureau for Janssen Cilag; has received a travel grant from ProteoMEdiX; has received institutional honoraria for participation in advisory boards from Bayer, Janssen Cilag, Roche, AAA International, Amgen, Menarini Silicon Biosystems, Astellas Pharma, Tolero Pharmaceutcials, MSD, Pfizer, Telixpharma, BMS, and Orion; and holds patent royalties and other intellectual property for a research method for a biomarker (WO2009138392).