Michler's ketone (4,4' bis(N,N‐dimethylamino)benzophenone) mk is a potential ultraviolet radiation (UVR) absorber in various materials. In this study, we have tested the UVR filtering ability of mk on cotton fabric. The beta‐cyclodextrin (β‐CD) inclusion complex of mk enhances ultraviolet protection factor (UPF) drastically. The impact of β‐CD on the UVR filtering of mk are demonstrated by investigating the guest (mk:absorbers)‐host (β‐CD:enhancer) inclusion complex. Spectral and molecular docking analysis of mk:β‐CD complex infers the vertical insertion of the guest molecule by positioning ‐C=O group of mk at the center of the host molecule with the exclusion of the terminal atoms of guest molecule outside the β‐CD cavity. Thus, the host; β‐CD renders an inflexible fit to the guest:mk. The inflexible fit of mk into the β‐CD cavity enhances the UVR dissipation when it is incorporated on the poplin cotton fabric. With UPF = 46 mk:β‐CD complex is proposed as a potential UVR absorber suitable for manufacturing sun protective textiles. The holding of mk by β‐CD enhances the UVR dissipation and hence facilitates the native red‐shifted emission and non‐radiative relaxation by the formation of twisted intramolecular charge transfer in mk. [ABSTRACT FROM AUTHOR]