Access to α,α-Difluoro-γ-amino Acids by Nickel-Catalyzed Reductive Aryldifluoroacetylation of N -Vinylacetamide.
- Resource Type
- Article
- Authors
- Zhao, Qing-Wei; Yang, Zhi-Fang; Fu, Xia-Ping; Zhang, Xingang
- Source
- Synlett. 2021, Vol. 32 Issue 15, p1565-1569. 5p.
- Subject
- Language
- German
- ISSN
- 0936-5214
A nickel-catalyzed reductive aryldifluoroacetylation of N -vinylacetamide with ethyl chloro(difluoro)acetate and aryl iodides is described. This chelating amide carbonyl group-assisted strategy provides rapid access to a variety of protected α,α-difluoro-γ-amino acids that might have potential applications in peptide chemistry and protein engineering. An advantage of this method is its synthetic simplicity, with no preparation of organometallic reagents. [ABSTRACT FROM AUTHOR]