Objective: The purpose of this study was to analyze and compare different kinds of outdoor walking shoes in terms of muscle fatigue and ground reaction force on walking, and to provide foundational data for developing and choosing outdoor walking shoes that fit the users. Method: The study subjects were 30 healthy men. The experiment was conducted by using outdoor walking shoes with different inner and outer harnesses of the midsole, and shapes of the outsole. For data collection, electromyography was used to measure the muscle fatigue of the anterior tibial muscle and gastrocnemii, which contribute to the dorsiflexion and plantarflexion of the ankle joint, and the biceps muscle of the thigh and lateral great muscles, which contribute to the flexion and extension of the knee joint. A GRF measurement device was used to measure the X, Y, and Z axes. Results: In the type A outdoor walking shoes, regarding the hardness of the midsole, the inner part was soft, while the outer part was hard. The vertical ground reaction force was the lowest, which means least impact while walking and light load to the knees and ankles. The type C outdoor walking shoes were intended to provide a good feel in wearing the shoes. The tibialis anterior, biceps femoris, and gastrocnemii indicate low fatigue, which means that during a long-distance walk, it will minimize the fatigue in the muscles of the lower limbs. Conclusion: To sum up the study results, the different types of outdoor walking shoes indicate their unique characteristics in the biomechanical comparison and analysis. However, the difference was not statistically significant. Thus, a systematic and constant follow-up research should be conducted to cope with expanding market for outdoor walking shoes. Lastly, this study is expected to present foundational data and directions for developing outdoor walking shoes.