Purpose: We aimed to investigate the effect of metal ions from oral prostheses (OPs) released into the saliva of patients with orallichenoid lesions (OLLs). Materials and Methods: Subjects (n=183) were divided into four groups according to the presence or absence of OLL and OP. Concentrations of the metal ions titanium, chromium (Cr), cobalt (Co), nickel (Ni), palladium (Pd), silver (Ag), platinum (Pt),gold (Au), and zirconium (Zr) were measured using a laser-ablation microprobe inductively coupled to a plasma mass spectrometer. Saliva levels of interleukin (IL)-6, IL-1β, IL-8, and tumor necrosis factor-α were detected using an enzyme-linked immunosorbentassay. The reticulation/keratosis, erythema, and ulceration (REU) scoring system was used to assess the severity of OLL. Results: Mean concentrations of IL-6 and IL-8 were statistically higher in OLL patients with OPs. The concentration of Ni washigh in OLL groups. The concentrations of Cr, Ni, and Au ions in the saliva were positively correlated with IL-8. REU scores werepositively correlated with salivary concentrations of IL-6 and IL-8, as well as with concentrations of Cr, Ni, and Au. Conclusion: Increased concentrations of metal ions, especially Ni, in saliva were positively correlated with IL-8 and showed positivecorrelations with the severity of OLL.