Uranium waste, which is one of the wastes containing radioactive substances of natural origin, is generated in association with the use of nuclear power generation. While there have been long discussions about handling and disposal of the uranium wastes for last 50 years in Japan, its clear vision including a specific disposal site has not yet been received. For improving this situation, the authors perceived that it is necessary to refocus this issue from the view of humanities and social sciences, rather than that of natural science and engineering and have had in-depth discussions in a specialized study group established in the Japan Health Physics Society. This commentary provides an overview of the two-year discussions in that group.