In a pandemic-era society, modern people need psychological healing. Monet frequently used the instantaneous phenomena of nature and nature that are changed by light as the subject of landscape painting. These natural factors have healing effects, which can have a positive effect on human psychoactivity and solve the psychological problems experienced by modern people. Therefore, the purpose of this study is to analyze the colors that Monet used for natural factor expression and use them in biophilic design color planning in the building environment and ultimately provide a healing space. After analyzing the natural factors expressing the color, the use possibility of 5-color was identified through the exploring of a simulation image of the interior design application. The method of this study is as follows; Firstlly, for a general understanding of the landscape painting images used in the analysis, the themes covered in the landscape paintings of the Impressionists and Monet were examined and the characteristics of color that express natural elements were identified. In addition, by examining the chromatic expression characteristics of biophilic design, the relevance of color expression between natural elements and Earth-tone was examined. Secondly, the color series for the 5 colors extracted from each landscape painting image is classified, and the blackness and chromaticness are analyzed by calculating the average value of the nuance. NCS Basic 8 colors are analyzed, and the distribution ratio of each natural element is analyzed by creating a qualitative sheets for each color series that records natural elements based on the NCS Code. A nuance matrix was created based on the NCS Code and a nuance comprehensive analysis was performed while determining the association with Earth-tone. The NCS isochromatic triangle is used to analyze the nuances of the natural elements of the most extracted colors. Thirdly, a simulation of the application of natural elements of color expression is explored to examine usability. The results of analyzing the color expression characteristics of natural factors are as follows; In the analysis of the average blackness and average chromaticness(nuances average value) used in landscape painting, it was found to have characteristics of medium and low brightness, and midium saturation. The GY series was analyzed at 31%(165 times) and showed the most used color for natural factor expression. It was extracted most from grass, trees and mountains. In the nuance comprehensive analysis(nuance matrix), the composition of the medium brightness and low saturation, high brightness and medium saturation, high brightness and low saturation was shown in the nuance total analysis with high frequency. Blackness and Chromaticness characteristics were derived from the NCS isochromatic triangle analysis of G90Y. The use of qualitative sheets for natural factor analysis and analysis by introducing a nuance matrix is a discriminatory feature of this study.