Quantitative Photoacoustic Tomography Using Iteratively Refined Wavefield Reconstruction Inversion: A Simulation Study
- Resource Type
- Periodical
- Authors
- Ranjbaran, S.M.; Aghamiry, H.S.; Gholami, A.; Operto, S.; Avanaki, K.
- Source
- IEEE Transactions on Medical Imaging IEEE Trans. Med. Imaging Medical Imaging, IEEE Transactions on. 43(2):874-885 Feb, 2024
- Subject
- Bioengineering
Computing and Processing
Optical imaging
Biomedical optical imaging
Optical scattering
Acoustics
Tomography
Optimization
Image reconstruction
Iteratively refined wavefield reconstruction inversion
alternating direction method of multipliers
fluence compensation
quantitative photoacoustic tomography
speed of sound estimation
- Language
- ISSN
- 0278-0062
1558-254X
The ultimate goal of photoacoustic tomography is to accurately map the absorption coefficient throughout the imaged tissue. Most studies either assume that acoustic properties of biological tissues such as speed of sound (SOS) and acoustic attenuation are homogeneous or fluence is uniform throughout the entire tissue. These assumptions reduce the accuracy of estimations of derived absorption coefficients (DeACs). Our quantitative photoacoustic tomography (qPAT) method estimates DeACs using iteratively refined wavefield reconstruction inversion (IR-WRI) which incorporates the alternating direction method of multipliers to solve the cycle skipping challenge associated with full wave inversion algorithms. Our method compensates for SOS inhomogeneity, fluence decay, and acoustic attenuation. We evaluate the performance of our method on a neonatal head digital phantom.