Frequency-comb based optical ranging and synchronization has the potential to support future space-based distributed sensing. However, comb-based systems cannot yet meet the requirements on size/weight and power (SWaP) needed for space-based operation even though the performance of these systems can achieve extremely high precision and accuracy. Here, we describe a ground-based experiment that demonstrates progress on utilizing low size/weight and power frequency combs, data processing and optical terminals for precision ranging measurements over free space. The small platforms and techniques described here are a first step towards future integration onto a spacecraft platform.