This research was done in two towns of Granma in order to evaluate the agronomic response of pepper cultivars, “Spanish” variety, under drought stress conditions and with the application brassinosteroids (Biobrás - Plus). In the town of Jiguaní the research was done at Las Marianas market garden, and in the town of Guisa the research was done at Río de Guisa market garden. The biostimulant was applied to foliage 15 days after being planted and at bloom initiation, early in the morning. The growth rate was evaluated every 10 days, and at harvest the yield and their components were evaluated. In order to assess the response of the variables, an analysis of the main components was carried out. Among the variables that had a better response to the treatments were: the total number of the fruits per plant, polar and equatorial diameter of fruits and average weight, average mesocarp thickness and the yield of the cultivar. The results showed that the biostimulant utilized had a high anti stress effect, the best results were achieved when applied to plants that were under drought stress conditions.