Thyrotropinoma and multinodular goiter: A diagnostic challenge for hyperthyroidism
- Resource Type
- article
- Authors
- Duygu Yazgan Aksoy; Arzu Gedik; Nese Cinar; Figen Soylemezoglu; Mustafa Berker; Omer Alper Gurlek
- Source
- Journal of Research in Medical Sciences, Vol 18, Iss 11, Pp 1008-1010 (2013)
- Subject
- Central hyperthyroidism
thyrotropinoma (TSHoma)
TSH-secreting adenoma
toxic goiter
toxic nodular goiter
Medicine
- Language
- English
- ISSN
- 1735-1995
1735-7136
Thyroid disorders are frequently encountered. The diagnosis is straightforward unless clinical or laboratory findings are inconclusive and/or perplexing. Hyperthyroidism due to a thyrotropin-secreting pituitary adenoma rarely occurs and symptoms due to thyroid hormone excess are subtle. The presentation of the disease becomes unusual when co-secretion of other hormones with thyrotropin or concomitant thyroid parenchymal pathology exist. We present the case of a 63-year-old female patient with thyrotropinoma co-secreting growth hormone and multinodular goiter. She developed hyperthyroidism first due to thyrotropinoma and later due to a toxic nodule. Herein, we discuss the diagnostic and therapeutic challenges of hyperthyroidism with atypical presentation.