Enrofloxacin/florfenicol loaded cyclodextrin metal-organic-framework for drug delivery and controlled release
- Resource Type
- article
- Authors
- Yucai Wei; Chaoxi Chen; Shuo Zhai; Min Tan; Juebo Zhao; Xiaowen Zhu; Lu Wang; Qun Liu; Tao Dai
- Source
- Drug Delivery, Vol 28, Iss 1, Pp 372-379 (2021)
- Subject
- γ-cyclodextrin
metal-organic framework
antibacterial ability
Therapeutics. Pharmacology
RM1-950
- Language
- English
- ISSN
- 1071-7544
1521-0464
10717544
We presented an antibiotic-loaded γ-cyclodextrin metal-organic framework that delivered antibiotics suitable for the treatment of bacterial infections. The γ-cyclodextrin metal-organic framework was developed using γ-cyclodextrin and potassium ion via the ultrasonic method. The antibiotic (florfenicol and enrofloxacin) was primarily encapsulated into the pore structures of γ-CD-MOF, which allowed the sustained release of antibiotics over an extended period of time in vitro and in vivo. Notably, antibiotics-loaded γ-CD-MOF showed much superior activity against bacteria than free antibiotics (lower MIC value) and displayed better long-lasting activity (longer antibacterial time). The antibiotics-loaded γ-CD-MOF showed nontoxic and perfect biocompatibility to mammalian cells and tissues both in vitro and in vivo. These materials thus represent a novel drug-delivery device suitable for antibiotic therapy. This research is of great significance for reducing the generation of bacterial resistance and providing new ideas for the application of γ-CD-MOF.