Facilitating the transmetalation step with aryl-zincates in nickel-catalyzed enantioselective arylation of secondary benzylic halides
- Resource Type
- article
- Authors
- Weichen Huang; Mei Hu; Xiaolong Wan; Qilong Shen
- Source
- Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
- Subject
- Science
- Language
- English
- ISSN
- 2041-1723
Fluoroalkyl groups are widely found in pharmaceutical products. Here, the authors report a highly enantioselective nickel-catalyzed cross coupling method for the construction of fluoromethylated stereogenic centers via a highly reactive zincate species facilitating the transmetalation step in the nickel catalytic cycle.