Introduction Thrombectomy catheters with a unique angled‐tip design (ZoomTM Aspiration Catheters, Imperative Care Inc., Campbell, CA) have recently emerged as promising devices for treating acute ischemic stroke. The angled‐tip configuration is engineered to enhance device trackability and optimize clot engagement. Following promising initial results observed during our catheter evaluation, we integrated these novel catheters into the majority of thrombectomy procedures at our institution. In this study, we aimed to determine whether the utilization of angled‐tip catheters could lead to reduced procedural expenses and shorter time to reperfusion in our patient population. Methods We conducted a retrospective single‐center cohort study involving consecutive patients with acute ischemic stroke due to large and medium vessel occlusions. All patients were treated by a single operator between January 2020 and March 2023. Patients treated within the 18‐month period preceding the introduction of the Zoom aspiration catheters using traditional straight‐tip catheters were assigned to the straight‐tip group, while those treated with the Zoom aspiration catheters were assigned to the angled‐tip group. Our primary analysis was a cost comparison between the angled‐tip and straight‐tip groups using the list prices associated with each device employed in the procedures. The secondary analysis was focused on safety and procedural outcomes including self‐adjudicated modified Thrombolysis in Cerebral Infarction (mTICI) reperfusion scores and time from puncture to reperfusion. Frequencies were compared using the Fisher’s exact test and means were compared using a two‐sample t‐test. P‐values