A maximum-entropy model to predict 3D structural ensembles of chromatin from pairwise distances with applications to interphase chromosomes and structural variants
- Resource Type
- article
- Authors
- Guang Shi; D. Thirumalai
- Source
- Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
- Subject
- Science
- Language
- English
- ISSN
- 2041-1723
Here the authors develop a computational method based on the maximum entropy principle to construct the structural ensemble of genomes using imaging data. The work reveals three-way contacts between loci and extensive conformational heterogeneity.