Cyr61在肿瘤中的作用及临床应用前景 / The role of Cyr61 in tumors and its clinical application
- Resource Type
- Academic Journal
- Authors
- 吴聪莲; 祝先进; 曹颖平; Wu Conglian; Zhu Xianjin; Cao Yingping
- Source
- 中华检验医学杂志 / Chinese Journal of Laboratory Medicine. 39(8):571-574
- Subject
- 肿瘤
CCN胞间信号蛋白质类
富含半胱氨酸蛋白质61
整合素类
Neoplasms
CCN intercellular signaling proteins
Cysteine-rich protein 61
Integrins
- Language
- Chinese
- ISSN
- 1009-9158
富含半胱氨酸蛋白61( Cyr61)是一种分泌型基质蛋白,广泛参与调控细胞多种功能。近来的研究显示,Cyr61在肿瘤的发生、发展中扮演重要的角色,现认为其可能是一新的潜在促肿瘤形成因子,发挥着类似“癌基因”的作用。本文就近年来Cyr61与肿瘤发生发展关系的研究进展及在肿瘤诊断及治疗中的应用前景进行简要的归纳。(中华检验医学杂志,2016,39:571-574)
Cyr61/CCN1 is a secreted extracellular matrix ( ECM) protein, which has been shown to regulate a multitude of cellular responses.Many researches indicate that Cyr61 plays important roles in oncogenesis and development of tumor and is considered to be a novel potential oncogene.This review would provide a comprehensive summary about the roles of Cyr61 in the diagnosis and treatment of tumor.