目的 通过分析贝赫切特病患者的临床特点,研究其疾病活动性评价方法,以指导临床诊治.方法 回顾性分析吉林大学中日联谊医院2007至2014年116例贝赫切特病患者的性别、年龄分布及多系统受累的临床特点.首次对比分析了中国患者贝赫切特病近期活动性量表(BDCAF)和电子病历疾病活动性指数(EMRAI)与患者临床指标的相关性,并提出临床应用建议.结果 患者年龄多为21 ~40岁,平均病程4年,男性病程(9.5年)比女性(4.0年)更长(P<0.05),而且男性血管病变更常见(11.9%比1.36%,P<0.05);女性年龄分布更广泛,结节红斑更多见.BDCAF与EMRAI评分呈明显正相关,前者与血液多种炎性指标明显相关,后者应用更为简便.结论 不同性别的贝赫切特病患者临床表现存在差异,BDCAF与EMRAI评分方法与多种实验室炎性指标相关,能很好地反映疾病活动性,可用于指导临床评估病情及调整治疗方案.
Objective The clinical features and two disease activity assessment methods of Beh(c)et's disease were evaluated in order to guide clinical management.Methods A total of 116 patients with Beh(c)et's disease from China-Japan Union Hospital of Jilin University in 2007-2014 were analyzed retrospectively for the gender and age distribution as well as clinical features of muhisystem involvement.The correlations of Beh(c)et's Disease Current Activity Form (BDCAF) and electronic medical record (EMR)-based activity index (EMRAI) scoring systems with clinical data were compared in Chinese patients for the first time,and clinical suggestion was raised.Results Beh(c)et's disease was commonly seen in young adults with age between 21-40 years old with mean course of four years.Males had longer duration than females (9.5 years vs 4.0 years,P < 0.05),and vasculopathy was more commonly seen in males (11.9% vs 1.36%,P < 0.05),while females had wider age distribution.BDCAF and EMRAI scoring systems were positively correlated with each other;the former was well associated with laboratory inflammatory indices,and the latter was simplified for application.Conclusions The clinical manifestation of Beh(c)et's disease varies with different gender;BDCAF and EMRAI scoring system well correlate with the laboratory inflammatory indices of patients,and can indicate the disease activity.