PDF - 386KB, S1 Dual recombinase strategy for producing a "clean" loxP-floxed Hsd11b2. S2. The targeted events were confirmed with PCR and Southern analysis in F1 mice. S3. Inhibition of the COX-2 pathway had no effect on the activity of retinoblastoma protein and mTOR. S4. Glucocorticoids increased the activity of the tumor suppressor retinoblastoma protein and decreased the activity of mTOR pathway in cultured colonic cancer cells. S5. Inhibition of mTOR activity or inhibition of COX-2 activity did not affect the expression levels of p53 and p21 and REDD1.