Genetics of heart rate in heart failure patients (GenHRate)
- Resource Type
- Authors
- Juan Maya; Kaleigh L. Evans; Andrew Hamer; Ruicong She; Hongsheng Gui; David E. Lanfear; Heidi S. Wirtz; Jia Li; Christophe Depre
- Source
- Human Genomics, Vol 13, Iss 1, Pp 1-11 (2019)
Human Genomics
- Subject
- Male
Candidate gene
Chromosomes, Human, Pair 22
lcsh:Medicine
Genome-wide association study
030204 cardiovascular system & hematology
Cohort Studies
0302 clinical medicine
Risk Factors
Drug Discovery
African Americans
0303 health sciences
education.field_of_study
Framingham Risk Score
Ejection fraction
Middle Aged
Cadherins
3. Good health
Cardiology
Molecular Medicine
Female
Primary Research
medicine.medical_specialty
lcsh:QH426-470
Population
Heart rate
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
03 medical and health sciences
Internal medicine
medicine
Genetics
Humans
Genetic Predisposition to Disease
education
Molecular Biology
Aged
030304 developmental biology
Heart Failure
business.industry
lcsh:R
Stroke Volume
Single nucleotide polymorphisms
medicine.disease
Black or African American
lcsh:Genetics
Connexin 43
Heart failure
business
Genome-Wide Association Study
- Language
- English
- ISSN
- 1479-7364
Background Elevated resting heart rate (HR) is a risk factor and therapeutic target in patients with heart failure (HF) and reduced ejection fraction (HFrEF). Previous studies indicate a genetic contribution to HR in population samples but there is little data in patients with HFrEF. Methods Patients who met Framingham criteria for HF and had an ejection fraction