ROS-triggered cycle amplification effect: A prodrug activation nanoamplifier for tumor-specific therapy
- Resource Type
- Authors
- Zeqian Huang; Yaqing Ding; Yong Luo; Meixu Chen; Zishan Zeng; Tao Zhang; Yue Sun; Yanjuan Huang; Chunshun Zhao
- Source
- Acta biomaterialia. 152
- Subject
- Biomedical Engineering
General Medicine
Biochemistry
Biomaterials
Cell Line, Tumor
Neoplasms
Tumor Microenvironment
Humans
Nanoparticles
Prodrugs
Ditiocarb
Reactive Oxygen Species
Molecular Biology
Copper
Biotechnology
- Language
- ISSN
- 1878-7568
Selective in situ activation of prodrugs or generation of bioactive drugs is an important approach to reducing the side effects of chemotherapy. Herein, a tailored ROS-activable prodrug nanomedicine (Cu-SK@DTC-PPB) was developed as the prodrug activation nanoamplifier for highly selective antitumor therapy. Cu-SK@DTC-PPB was rationally constructed by the diethyldithiocarbamate (DTC) prodrug DTC-PPB and the nanoscale coordinated framework Cu-SK based on copper and the ROS generator shikonin (SK). Cu