Introduction : Two-dimensional technique (2DRT) is most commonly used in Indonesia. This technique causes severe late toxicity particularly in nasopharyngeal cancer (NPC). Radiation techniques such as Intensity-Modulated Radiation Therapy (IMRT) and Three-Dimensional Conformal Radiation Therapy (3DCRT) provide larger doses at the site of NPC while preserving normal tissue. This study aims to compare late side effects and quality of life (QoL) between IMRT and 2DRT groups. Method : This was a cross-sectional study with consecutive sampling. Salivae samples were collected at least 6 months after last radiation date. Xerostomia severity were determined by measuring whole saliva flow rate which then categorized based on Common Terminology Criteria for Adverse Events (CTCAE). European Organization for Research and Treatment of Cancer (EORTC) core questionnaire and EORTC head and neck module (QLQ-H&N35) wereused to assess QoL. Result: The IMRT group had higher saliva flow rate than 2DRT group (1,085 ±0,409 vs 0,188 ± 0,219 stimulated, 0,500±0,254 vs 0,196 ±0,156 unstimulated, p