Evaluation of lumbar intervertebral disc degeneration using dual energy CT virtual non-calcium imaging
- Resource Type
- Authors
- Fumiaki Sasaki; Tomomi Ohmura; Toshihide Itoh; Takuro Endo; Toshibumi Kinoshita; Yuki Shinohara
- Source
- European journal of radiology. 124
- Subject
- Adult
Male
Imaging biomarker
Degeneration (medical)
Intervertebral Disc Degeneration
030218 nuclear medicine & medical imaging
Radiography, Dual-Energy Scanned Projection
03 medical and health sciences
0302 clinical medicine
Lumbar
Medicine
Humans
Radiology, Nuclear Medicine and imaging
Intervertebral Disc
Lumbar intervertebral disc
Rank correlation
Aged
Retrospective Studies
Aged, 80 and over
Lumbar Vertebrae
business.industry
General Medicine
Middle Aged
Mr imaging
Magnetic Resonance Imaging
030220 oncology & carcinogenesis
Significant positive correlation
Radiographic Image Interpretation, Computer-Assisted
Female
Dual energy ct
business
Nuclear medicine
Tomography, X-Ray Computed
Biomarkers
- Language
- ISSN
- 1872-7727
Purpose To clarify the utility of dual energy CT (DECT) virtual non-calcium (VNCa) imaging for investigating lumbar intervertebral disc degeneration. Method Fifty-three patients who underwent both DECT and MR imaging were retrospectively reviewed. Midsagittal T2-weighted imaging findings of all discs were classified based on modified Pfirrmann grade (mPG). Quantitative evaluation of VNCa maps was achieved by setting volumes of interest on each disc. We compared VNCa CT values with mPG using Spearman’s rank correlation and one-way ANOVA. VNCa imaging findings of each disc were classified by two neuroradiologists into one of three categories based on the attenuation of nucleus pulposus (NP) compared to that of annulus fibrosus (AF) or muscle. The relationship between the visual categories for each rater and mPGs was analyzed by chi-square test. Statistical significance was established at P Results Among the included 171 lumbar discs, significant positive correlation was found between VNCa CT values for NP and mPGs (R2 = 0.574, P Conclusions VNCa imaging acquired by a single DECT scan and post-processing has potential as an imaging biomarker of lumbar intervertebral disc degeneration.