Additional file 1. Supplemental Table 1. Loadings for each of the top nine principal components. Supplemental Table 2. Definitions of housing quality indicators. Supplemental Table 3. Associations between housing quality indicators and epigenetic mortality risk score. Supplemental Table 4. Associations between PC7 and CpGs which compose the eMRS stratified on neighborhood greenspace. Supplemental Table 5. Pearson correlation (r2) between DNA methylation-derived cell counts and the neighborhood quality principal components used in the analyses. Supplemental Table 6. Associations between PC7 and the epigenetic mortality risk score after additional adjustment for cell counts. Supplemental Figure 1. Distribution of the epigenetic mortality risk score (eMRS) in Detroit Neighborhood Health Study participants. Supplemental Figure 2. Distribution of the percentage of large mature trees observed in the neighborhoods for the study participants. Supplemental Figure 3. Histogram of the distribution of community gardens observed within the neighborhoods for the study participants.