Background: Human Immune-deficiency Virus (HIV) infection is a public health problem worldwide, with the greatest burden in low-income settings. Increased survival associated with the use of anti-retroviral treatment is associated with an increase in the burden of cardiovascular disease (CVD). Primordial prevention of CVD requires an adequate knowledge, attitude, and practice of the risk factors.Aim: Assess the knowledge, Attitude, and Practices (KAP) of CVD risk factors in adults with HIV infection in Cameroon.Methods: We carried out a KAP survey at the Yaounde Central Hospital. Participants were consenting adults with HIV, aged > 18 years, of both sex who received regular care at the day hospital. Each participant had a face-to-face interview with a trained investigator using a standardized questionnaire.Results: A total of 329 participants were interviewed. Their mean age was 46.6 ± 10.6 years. Ten (3%) participants had good knowledge of CVD risk factors. Higher level of education was associated with good Knowledge (OR: 3.9, [95% CI: 2 – 7.6], p