Background: Knowledge translation (KT) is an important means of improving health service quality. Most research on the effectiveness of KT strategies has focused on individual strategies, i.e., those targeting directly the modification of allied health professionals’ knowledge, attitudes, and behaviours, for example. In general, these strategies are moderately effective in changing practices (maximum 10% change). Effecting change in organizational contexts (e.g., change readiness, general and specific organizational capacity, organizational routines) is part of a promising new avenue to service quality improvement through the implementation of evidence-based practices.Methods: A realist review will be conducted to explore the various organizational KT strategy action mechanisms (how, why, for whom, to what extent and under what circumstances) with a view to facilitating the choice of effective strategies for sustainable implementation of evidence-based practice for allied health professionals in traumatology settings. The review will begin by presenting initial theories developed by the research team, followed by the search for evidence, the selection of literature on context-mechanism-outcome configurations related to organizational KT strategies, and end with a refinement of initial theories and a synthesis.Discussion: Using a systematic and rigorous method, this review will help guide decision makers and researchers in choosing the best organizational strategies to optimize the implementation of evidence-based practices.Registration: This protocol has been submitted for registration on the PROSPERO database on October 30, 2020 (ID: 216105).