Non-invasive high-frequency oscillatory ventilation in preterm infants after extubation: a randomized, controlled trial
- Resource Type
- Authors
- Jiayan Yao; Liping Yao; Wei Tan; Xinnian Pan; Yan Mo; Wei Dai; Yan Li; Lingxiao Li; Dan Zhao; Danni Zhong; Qiufen Wei
- Source
- Journal of International Medical Research, Vol 49 (2021)
The Journal of International Medical Research
- Subject
- Prospective Clinical Research Report
Medicine (General)
Gestational Age
Biochemistry
Intermittent Positive-Pressure Ventilation
law.invention
03 medical and health sciences
R5-920
0302 clinical medicine
Randomized controlled trial
invasive ventilation
law
post-extubation
030225 pediatrics
bronchopulmonary dysplasia
medicine
Humans
Noninvasive Ventilation
Continuous Positive Airway Pressure
nasal continuous positive airway pressure
Oscillatory ventilation
business.industry
Biochemistry (medical)
Non invasive
Infant, Newborn
non-invasive high-frequency oscillatory ventilation
Infant
Cell Biology
General Medicine
medicine.disease
030228 respiratory system
Bronchopulmonary dysplasia
Anesthesia
Preterm infant
Airway Extubation
business
Infant, Premature
High frequency oscillatory ventilation
- Language
- ISSN
- 1473-2300
0300-0605
Objective To investigate the effectiveness and safety of non-invasive high-frequency oscillatory ventilation (NHFOV) in post-extubation preterm infants. Methods This was a randomized, controlled trial. A total of 149 preterm infants aged between 25 to 34 weeks’ gestational age with a birth weight of Results A total of 139 preterm infants finally completed the study. The reintubation rate was significantly lower in the NHFOV group than in the other groups. The duration of non-invasive ventilation and the length of hospital stay in the NHFOV and NIPPV groups were significantly shorter than those in the NCPAP group. The incidence of bronchopulmonary dysplasia in the NHFOV and NIPPV groups was significantly lower than that in the NCPAP group. The NHFOV group had significantly less nasal injury than the NCPAP group. Conclusion As post-extubation respiratory support in preterm infants, NHFOV has a lower reintubation rate compared with NCPAP and NIPPV, without increasing the rate of complications.