Background:The premature ruptureof membrane(PROM) is a controversial issue in midwifery thatpreventioneffortscannot be donebecause theexact etiologyhasnot been acknowledged.ThePROMmaylead to infection tomother andbaby,hence may increase themorbidityandmortalityof mothersandbabies.Objectives:To investigate the etiology of prematureruptureof membrane(PROM) viewed from gemelly,polihidramnion, distency of uterus, and fetal stressfactors.Methods:The study wasadescriptive researchand useddocumentationstudymethod. Thesamplesusedwas111records in 2013 atPanembahan Senopati Bantul Hospital.Results :Theetiologyof the PROM in Panembahan Senopati Bantul Hospital were fetal stress (45%),distency of uterus (41,4%), polihidramnion (10,8%) andthe least was gemelly (2,7%).Conclusion :The most frequent etiology of thePROMat Panembahan Senopati Bantul Hospital in 2013wasfetal stress (45%).