Alcohol challenge and sensitivity to change of the essential tremor rating assessment scale
- Resource Type
- Authors
- Mark Hallett; Gayle McCrossin; Sule Tinaz; Emily Lines; Aaron Artiles; Bernhard Voller; Dietrich Haubenberger; Codrin Lungu
- Source
- Movement Disorders. 29:555-558
- Subject
- medicine.medical_specialty
Essential tremor
Breath alcohol
Alcohol
Assessment scale
medicine.disease
Confidence interval
Correlation
chemistry.chemical_compound
Neurology
chemistry
Physical therapy
medicine
Neurology (clinical)
Analysis of variance
Sensitivity to change
Psychology
- Language
- ISSN
- 0885-3185
Background The ability of the Essential Tremor (ET) Rating Assessment Scale (TETRAS) to detect changes in tremor severity is unknown. Methods Fifteen adult ET patients received a single oral ethanol dose calculated to reach 0.05 g/dL breath alcohol content (brAC). Effects were investigated independently with accelerometry and TETRAS. Results Accelerometry data were log-transformed and a cumulative score logACC(R+L) was calculated. Correlation between logACC(R+L) and TETRAS was significant. TETRAS and accelerometry showed a significant effect of time point using repeated-measures analysis of variance. The difference between baseline and each of the following six time points as well as the correlation of TETRAS with brAC were significant. The calculated minimum detectable change of TETRAS was 8.9% and the effect size was d = 4.75 (95% confidence interval: 3.60–5.90). Conclusion We demonstrated sensitivity to change of the TETRAS performance scale after a therapeutic intervention, which further establishes its potential for use in both clinical and research settings. © 2013 International Parkinson and Movement Disorder Society