The article discusses a study which examined the exome sequencing on colorectal cancer (CRC) cases to identify the novel loci. Topics discussed include the validated and replicated missense variants located within the CRC linkage regions on chromosomes 1 and 15 and identification of the whole-exome sequencing DNA variants in multiple genes. It concludes with a suggestion for additional sequencing of exome to determine the role of variants in CRC susceptibility.