MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis
- Resource Type
- Article
- Authors
- Tong, Yin; Sun, Jianlong; Wong, Chi; Kang, Qingzheng; Ru, Beibei; Wong, Ching; Chan, April; Leung, Suet; Zhang, Jiangwen
- Source
- Genome Biology; December 2018, Vol. 19 Issue: 1 p1-17, 17p
- Subject
- Language
- ISSN
- 14747596; 1474760X
Aberrant promoter methylation is a common mechanism for tumor suppressor inactivation in cancer. We develop a set of tools to identify genome-wide DNA methylation in distal regions with causal effect on tumorigenesis called MICMIC. Many predictions are directly validated by dCas9-based epigenetic editing to support the accuracy and efficiency of our tool. Oncogenic and lineage-specific transcription factors are shown to aberrantly shape the methylation landscape by modifying tumor-subtype core regulatory circuitry. Notably, the gene regulatory networks orchestrated by enhancer methylation across different cancer types are seen to converge on a common architecture. MICMIC is available on https://github.com/ZhangJlab/MICMIC.